SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.
Identifieur interne : 001599 ( Main/Exploration ); précédent : 001598; suivant : 001600SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.
Auteurs : C. Wider [États-Unis] ; C. Vilari O-Güell ; M G Heckman ; B. Jasinska-Myga ; A I Ortolaza-Soto ; N N Diehl ; J E Crook ; S A Cobb ; J A Bacon ; J O Aasly ; J M Gibson ; T. Lynch ; R J Uitti ; Z K Wszolek ; M J Farrer ; O A RossSource :
- European journal of neurology [ 1468-1331 ] ; 2011.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Epistasis, Genetic (genetics), Female, Genetic Variation (genetics), Glycogen Synthase Kinase 3 (genetics), Glycogen Synthase Kinase 3 beta, Humans, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (ethnology), Parkinson Disease (genetics), Polymorphism, Single Nucleotide (genetics), Prospective Studies, Risk Assessment (methods), Young Adult, alpha-Synuclein (genetics), tau Proteins (genetics).
- MESH :
- chemical , genetics : Glycogen Synthase Kinase 3, alpha-Synuclein, tau Proteins.
- epidemiology : Parkinson Disease.
- ethnology : Parkinson Disease.
- genetics : Epistasis, Genetic, Genetic Variation, Parkinson Disease, Polymorphism, Single Nucleotide.
- methods : Risk Assessment.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Glycogen Synthase Kinase 3 beta, Humans, Male, Middle Aged, Prospective Studies, Young Adult.
Abstract
Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene-gene interactions between SNCA, MAPT, and GSK3B in association with PD.
DOI: 10.1111/j.1468-1331.2010.03297.x
PubMed: 21159074
Affiliations:
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Le document en format XML
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<term>Case-Control Studies</term>
<term>Epistasis, Genetic (genetics)</term>
<term>Female</term>
<term>Genetic Variation (genetics)</term>
<term>Glycogen Synthase Kinase 3 (genetics)</term>
<term>Glycogen Synthase Kinase 3 beta</term>
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<term>Middle Aged</term>
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<term>Parkinson Disease (ethnology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
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<term>Risk Assessment (methods)</term>
<term>Young Adult</term>
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<term>tau Proteins (genetics)</term>
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<term>Genetic Variation</term>
<term>Parkinson Disease</term>
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<term>Adult</term>
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<front><div type="abstract" xml:lang="en">Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene-gene interactions between SNCA, MAPT, and GSK3B in association with PD.</div>
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<name sortKey="Cobb, S A" sort="Cobb, S A" uniqKey="Cobb S" first="S A" last="Cobb">S A Cobb</name>
<name sortKey="Crook, J E" sort="Crook, J E" uniqKey="Crook J" first="J E" last="Crook">J E Crook</name>
<name sortKey="Diehl, N N" sort="Diehl, N N" uniqKey="Diehl N" first="N N" last="Diehl">N N Diehl</name>
<name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M J" last="Farrer">M J Farrer</name>
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<name sortKey="Ortolaza Soto, A I" sort="Ortolaza Soto, A I" uniqKey="Ortolaza Soto A" first="A I" last="Ortolaza-Soto">A I Ortolaza-Soto</name>
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